CBD Oil And The Endocannabinoid System

Cannabidiol, also known as CBD oil is a chemical compound extracted from hemp or cannabis sativa plant. CBD is known as an external source of cannabinoids. This article focuses on the interaction between CBD oil and the endocannabinoid system.

Endocannabinoid system is responsible for responding to endogenous cannabinoids found in the human body. Scientists have however proven that endocannabinoid system can still respond to external sources of cannabinoids such as CBD and phytocannabinoid cannabidiol. National health institute has issued a statement claiming that manipulation of the endocannabinoid system through external sources of cannabinoids is useful in the medical field for treating ailments that scientist did think had a cure.
cannabis oil

Cannabinoid Receptors and CBD

Endocannabinoid system has binding site receptor that is:

  • Cannabinoid Receptor 1
  • Cannabinoid Receptor 2

THC the psychoactive element of cannabis binds perfectly to CB1 and CB2 receptors, whereas, cannabidiol does not bind with either receptor perfectly. CBD will only stimulate the receptors activities without having to bind. The action caused will make any cell containing either of the receptors to change.

CB1 and CB2 work in a systematic manner as they are found throughout the body.

Indirect Effects of CBD on the Endocannabinoid System

Introducing CBD to endocannabinoid system triggers the release of 2-AGan endogenous cannabinoid. 2-AG also stimulates CB1 and CB2 receptors which will improve the body’s functions. National health institute has made an analysis showing cannabidiol inhibits activities of FAAH (Fatty Acid Amide Hydroxylase). Slowly the anandamide is damaged. Anandamide is another endogenous cannabinoid with important functions in the body.

If you are going to use this compound, you should get a high-quality tincture like the ones from https://www.nokacbdaustralia.com.au/.

More Effects of CBD

CBD has more effects on the human body other than stimulating the endocannabinoid system. They include:

  • CBD interacts directly with the G-protein receptor called TRPV-1. This protein is responsible for relieving inflammation, mediating pain perception and regulating body temperature.
  • Cannabidiol is known to activate the serotonin receptors.
  • CBD inhibits the ID-1 gene that is responsible for causing pancreatic, ovaries, lungs, brain, breast and several other severe forms of cancer.


Effects in Medicine

Cannabidiol’s interaction with the endocannabinoid system and other cells found in the human body. This interaction has proven its importance in treating a variety of illnesses. THC, for example, is used to treat the side effects that most cancer patients get as a result of chemotherapy. CBD contains 0.03% of THC which is applied in such instances. Note CBD and THC have a synergy effect hence the two substances should be administered together.
hemp leaves
Stimulation of the endocannabinoid system by CBD promotes homeostasis in the body, inhibits the inflammation process and reduces chronic pain. CBD works on systems and genes such as ID-1 gene. It is an indicator that CBD can be used in treating some types of cancers.

Take Away

More medical research is still being carried out and the list of illness treated by CBD oil is growing too. At the moment CBD treats conditions such as:

  • Stroke
  • Asthma
  • Glaucoma
  • Heart disease
  • Diabetes
  • Mood disorders
  • Epilepsy

Before using CBD oil it is important for patients to do their own research since cannabidiol cannot be mixed with other pharmaceutical drugs.



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